Role of epigenetic modifications in inflammation and cancer

Abstract

Epigenetic modifications which include histone modifications acetylation and DNA methylation play an important role in expression of genes. Epigenetic modifications play an important role in development, progression of diseases like cancers and also have an important role in inflammation related disorders. In this review we will try to focus on different histone, DNA modifications and their role in inflammation and cancer. Cancer cells show immune tolerance by activation and inhibition of genes associated with inflammation and inflammatory response. A sort of peripheral immune tolerance is shown by cancer cells like our self antigens are recognised.