A Review on Structural and Antibacterial Activities of Quinolones

Abstract

The aim of this paper to discuss about the quinolones. Quinolones shows amphoteric character due to the presence of both acidic and basic groups and having a great effect on antimicrobial field. It plays a crucial role in antibacterial drugs because most of the synthetic antibiotic contains quinolones and fluoroquinolones. The history of quinolones generated through the scientific and clinical awareness in 1960s. In this paper the structural activity relationship of antibacterial drugs containing quinolones and fluoroquinolone moieties has been discussed. The effect of different subsituients on different position of quinolones are also described. Along with this the antibacterial activity also considered  by the various substitution on quinolones in this paper.