Review Summary Fascin protein and tumor

Jafar Abdel- Hadi


Fascin protein is a member of the actin binding protein Fascin. Initially, Fascin protein was discovered by Bryan J et al. in sea urchin and ocyte in the 70s of the 20th century, and they conducted its separation and purification [1, 2, 3]. In 1993 through the cDNA sequential information of echinoderm’s Fascin protein [4], it was revealed that it featured homology with the Drosophila singed protein [5], human 55kD actin binding protein [6] and the orthologues in other vertebrates homology [7, 8, 9], and it was also found that they did not feature homology with other discovered actin binding protein; therefore, they were classified into a new actin binding protein family-Fascin protein family.

The mammalian genome encodes three Fascin genes, i.e. Fascin 1, Fascin 2 and Fascin 3. In humans, the gene that encodes Fascin1 is located at 7p22 of the chromosome, while those of Fascin 2 and Fascin 3 are respectively located at 17q25 and 7q31 [10, 11, 12]. Fascin 10 protein is widely distributed in mesenchymal tissue and the nervous system, while Fascin 2 and Fascin 3 are specially expressed in retina and testis. [8, 13, 14]. Although several kinds of Fascin protein have been found, currently the mostly studies is still human Fascin 1(hereinafter referred to as Fascin), and in this paper, it only

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