Study to Know the Bacterial Pathogens Causing Sepsis in Infants and Their Susceptibility to Antibiotics

Abstract

Objective: To determine the frequency of pathogen, antibiotic susceptibility and widely used antibiotic resistance patterns in sepsis in bacterial infected infants.

Place and duration of work: Central Laboratory, Services Hospital, Lahore for the period of 6 months .

Study design: Retrospective descriptive observational study.

 Patients and methods: During the study, all 1414 reports submitted to Civilian Hospital Karachi for culture / sensitivity to infants were analyzed for bacterial pathogens, frequency, susceptibility to antibiotics, and blood type of resistance.

 Results: 1414 babies had a positive blood culture in 604 (42.7%) . Gram-positive bacteria were more suppressed (54.1%) than Gram negative bacteria (45.9%). Male: female ratio was about 1: 0.9. Escherichia coli, and then 9 dominant organisms, Staphylococcus aureus and Pseudomonas aeruginosa, respectively, which were isolated. The overall sensitivity of the amikacin and cefotaxime was 60.87% and 36.67% respectively was used as empirical treatment. Hemorrhagic fever (56.21%), cephalosporins (55.9%), gentamycin (54.31%) and amoxicillin were very resistant (51.11%) when the microorganisms were more susceptible to vancomycin (95.54%), ciprofloxacin (94.16%).

Conclusion: Gram-positive organisms have been identified as the greatest threat to sepsis in infants, a model has been developed that is

resistant to commonly used antibiotics and is necessary to control the spread of these resistant strains by constant monitoring of infectious disease control programs and infection resistant patterns