Formulation and Evaluation of Gastro Retentive Floating Tablets of Quinapril HCL

Abstract

 Quinapril HCl is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure. Quinapril HCl has short half life (2 hrs). To reduce the frequency of administration and to improve patient compliance, gastro retentive floating system formulation is desirable. Thus it is decided to prolong the gastric residence time in terms of making floating gastro retentive drug delivery system to increase drug absorption and hence bioavailability.Totally 12 formulations were formulated by using the above drugs by using two different techniques like Effervescent floating technique and Non Effervescent floating technique. Among them Formulations F1-F12 were formulated by using Quinapril HCL as a drug, whereas the formulations F1-F6 were formulated by Effervescent floating technique and formulations F7-F12 were formulated by Non Effervescent floating technique.