Cd44 Gene Single Nucleotide Polymorphism: Impact On Efficacy Of Cd34+ Cell Mobilization In Autologous Haemopoietic Stem Cell Transplantation

Abstract

autologous hamopoietic  stem cell transplantation in stead of bone marrow stem cells . Mobilization of stem cells into peripheral blood can be affected my many factors such as: underlying diseases, prior treatment, age and genetic polymorphisms such as G-CSFR, adhesion molecules,VCAM-1,CD 44 and chemokines SDF -1. The CD44 is a cell adhesion molecule which shows high structural heterogeneity .CD44 is multifunctional glycoprotein receptor that binds various ligands like hyalouronic acid and ostopontin as these adhesion molecules play a critical role in HSCs homing in bone marrow, any abnormalities in these adhesion molecules can impair HSC lodgment in their bone marrow niche and mediate their mobilization to peripheral blood.