D- Optimal combination Designing and Statistical development of Nifedipine Transdermal Patch

Abstract

In the present study nifedipine transdermal patch were prepared and developed by using D-optimal combination design with poly vinyl pyrrolidone (PVP) and ethyl cellulose (EC) as rate controlling polymer . The formulated transdermal patches were evaluated for various parameters like drug excipients compatibility study, physicochemical evaluation studies, mechanical charecteristcs, In vitro drug release and permeation tests. The result of evaluation parameters demonstrated a successful optimization of transdermal patch.