The protective role of Epigallocatechin gallate on oxidative stress in Alzheimer rats chemically induced by Aluminum oxide nanoparticles

Abstract

Alzheimer’s disease (AD) is the most common cause of dementia. Epigallocatechin gallate (EGCG), as well as its most abundant polyphenol, is the most potent neuroprotective compound in green tea.

The aim of this study was to evaluate the possible protective effects of EGCG on oxidative stress in Alzheimer's disease induced by Aluminum oxide nanoparticles in rats. Eight groups of rats were used; Group1 (normal control n). Group 2 (AI₂O₃NPS-treated rats) . Group 3 (EGCG 5 mg/kg b.w -treated rats, n= 6). Group 4 (EGCG 10 mg/kg b.w-treated rats). Group 5 (Rivastigmine or Exelon-treated rats). Group 6 (AI₂O₃NPS + EGCG 5 mg/kg b.w). Group 7 (AI₂O₃NPS + EGCG 10 mg/kg b.w) . Group 8 (AI₂O₃NPS + Exelon, n=6). The study revealed that AI₂O₃NPS treated increase AChE, Aβ, BChE and MDA as well as the decrease in GSH, SOD and CAT. EGCG minimized the deteriorating effects of Aluminum oxide nanoparticles on biochemical parameters indicated by the decreased AChE, Aβ, BChE and MDA with the increased GSH, SOD and CAT.