Green Synthesis, Characterization and Bioactivity Study of few Transition Metal Complexes of Schiff base Ligand Derived from 2-Amino-5, 6-Dimethyl Benzimidazole &Benzil

Abstract

A green synthesis of tetra dentate Schiff base ligand was carried out by treating 2-Amino-5, 6-dimethyl benzimidazole with benzil in 2:1 molar proportion under solvent free condition in a scientific microwave oven. High yield was obtained after purification. Few metal complexes of Schiff base were synthesized by using Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ag(I) metal saltsunder solvent free condition in the same microwave oven. All metal complexes showed diverse color at the end of reaction and melting point of each complex confirmed the formation of the metal complex. An in depth characterization of both Schiff base & its representative metal complexes performed by different analytical & spectral techniques including elemental analysis, TLC, IR spectroscopy, ¹HNMR spectroscopy, LCMS, UV spectroscopy and TGA . Antimicrobial activity of Schiff base &it’s all metal complexeswere studied against Escherichia Coli, Staphylococcus Aureus & Salmonella Typhi showing significant bioactivity of the metal complexes and Schiff base ligand.