Ameliorative Potential of Bambara Nuts against Acute Ethanol-Induced Oxidative Stress in Wistar Rats

Abstract

The aim of this study is to examine the ameliorative potential of Bambara nuts against acute ethanol-induced oxidative stress in Wistar rats. Bambara nut, the Songkhla 1 variety were purchased at Obimze area of Owerri, Imo State Nigeria and ground into fine powder using a coffee grinder. Extraction was done using soxhlet apparatus and methanol as the solvent. Twenty-four adult male Wistar rats were acclimatized for seven days during which they were fed ad libitum with standard feed and drinking water. They were randomly divided into four groups of six rats each. Animals in groups A and B were administered distilled water while those in groups C and D were administered Bambara nutextract for twenty-one days at a dose of 100 mg/kg body weight 12 hourly via oral route. At the end of the treatment, they were fasted overnight and animals in groups B and D were exposed to a single dose of 70% ethanol at 12 ml/kg body weight to induce oxidative stress.