In vitro antibacterial activity study of endophytic fungi extracts from the medicinal plants Catharanthus roseus and Centella asiatica

Abstract

studied and screened for their antimicrobial potential. Several fungi were isolated from different parts of the plant, isolated from the leaves showed significant antimicrobial potential. The crude extract of this fungal isolate with Hexane, Ethyl acetate and Methanol were screened for their antimicrobial potential. The extract by ethyl acetate showed significant antimicrobial activity against E. coli, S. typhimurium, B. cereus, B. subtilis, K. pneumoniae and S. aureus. The antimicrobial activity was highest against E. coli, followed by S. typhimurium and B. cereus . The present study helped to justify the traditional use of Catharanthus roseus and Centella asiatica against human pathogenic bacteria. Further, it is confirmed that the antimicrobial activity is attributable to the presence of endophytic fungi. It also justifies that the studies on isolation and identification of these bioactive compounds can be a crucial approach to search of novel natural products.