Structure prediction and analysis of Human Dopamine Receptor-1

Abstract

Dopamine and its five different receptors play vital role in regulating the physiological functions of the human body. The receptors of dopamine neurotransmitter are crucial targets for pharmacological drugs for treatment of neurological disorders such as Schizophrenia, Parkinson’s disease. The experimental 3-Dimensional (3D) structure of human dopamine receptor-1 (DRD1) has not been reported in PDB yet. Determining the 3D structure of human dopamine receptor-1 (DRD1) may provide in-depth knowledge about its functional analysis and would help in drug designing. Various servers and software based on ab-initio method, threading and homology modeling are employed to generate full length 3D model of human dopamine receptor DRD1.  The structure validation was also performed to predict the best possible 3D model.

Keywords: Dopamine receptor-1 (DRD1); Structure prediction; Homology Modeling; Threading; Ab-initio method; Structure Validation.