Fabrication and characterization of water soluble vitamin loaded Poly (lactic-co-glycolic acid) aligned electrospun nanofibers

Abstract

Recent trend in nano biomaterial are focusing on combination of various biological molecules with natural or synthetic polymers to improve their physiochemical and mechanical properties. In present work we have blended the water soluble vitamin (B5)with PLGA solutions and fabricated vitamin loaded aligned nanofiber mash by electrospinning process. Material was further characterized for its morphology, mechanical strength and surface wettability properties.The average diameter of PLGA and PLGA/Vt-B5 nanofiber was noted560.12±88.46nm and 305.44±58.95nm respectively. The tensile strength was noted higher in PLGA nanofibers 24.16±1.82MPa as compared to PLGA/Vt-B5 nanofibers 19.49±1.38MPa respectively.However, by the addition of vitamin contact angle measurement were decreased from 126.01° to 117.23° in PLGA/Vt-B5 nanofibers.Present studied provideda basis for further application of this nanofibrous material in tissue engineering and drug delivery applications.

Key words: Electrospinning; water soluble vitamin; PLGA; Aligned nanofibers; Biomaterial.