Bio-Informatics Analysis Of Isoflavone Derivatives Against Aldose Reductase: A Key Enzyme In Diabetes Associated Cataract

Abstract

Aldose reductase inhibitors (ARI) provide a viable mode to fight against diabetic complications. Nevertheless to the date, most of the ARIs have met with the limited success, and some of the synthetic ARIs were associated with deleterious side effects or else poor penetration of target tissues such as nerve and retina. Therefore, a novel series of N-((5-phenyl-1H-imidazol-2-yl)alkyl)-2H-chromene-3-carboxamides were rationally designed based on natural isoflavonoids. The compounds were screened in vitro for Aldose reductase (ALR2) inhibitory activity.  Our in silico analysis and biochemical assays confirmed that 19 has the best inhibitory activity in this novel series of synthesized compounds. Design of N-(imidazole)-2H-chromene-3-carboxamides as aldose reductase inhibitors. Our Insilico analysis shows that 19 compound holds the promise to treat diabetic secondary complications.

19 in the active site groove of ALR2