Study of Various Biochemical Parameters in Patients of Myopathy with Hypothyroidism

Abstract

Background: Thyroid dysfunctions are common endocrine disorders. Muscle involvement in hypothyroidism is common with 30-80% of hypothyroid patients presenting with muscular symptoms varying from myalgia to true myopathy. Aims & objective:  The aim of this study was to find out relationship of various biochemical parameters in patient’s of myopathy with hypothyroidism.Materials and Methods: The present study was conducted on 100 hypothyroid patients attending the Medical OPD and Radio Immuno Assay (RIA) Laboratory of the Biochemistry Department of JLN Medical College & Hospitals, Ajmer, after taking approval from ethical committee. The results of patients were compared with 50 healthy control subjects of either sex of similar age group.  The blood samples were collected from all the attending patients  and analyzed for Various Serum Muscle Markers. These values were compared by P value. Results:All the muscle markers fraction were comparable to those of studied groups and they were significantly deranged, as compared to those of Group-I. A significant increased in the levels of  CK-NAC, LDH, AST and Myoglobin and non significant elevated level of CK-MB was observed in hypothyroid subjects as compared to the healthy control subjects. Conclusion : We found that these muscle markers along with thyroid profile can be used to determine the severity as well as for screening and early diagnosis of hypothyroidism and any associated underlying myopathy.