Emerging pattern of carbapenem resistant E.coli and Klebsiella species in Hospital and Community acquired infections from a rural setup.

Abstract

Antimicrobial resistance is a global problem that needs urgent action. Development of antimicrobial resistance is a phenomenon inevitably related to microbial evolution and antibiotic use. Carbapenem resistance (CR) producing enterobacteriacaeae has become a growing therapeutic concern worldwide.Aim of this study was to evaluate CR producing Escherichia coli and Klebsiella from all clinical isolates of hospital and community acquired infection.A total of 100 clinical isolates of carbapenem resistant strains of E.coli and Klebsiella species from all clinical samples were cultured and antibiotic sensitivity was done as per standard laboratory routine procedures.Among total (n=100) carbapenem resistant strains, 78% and 22% were HAI and CAI respectively. In HAI, CR strains of Klebsiella and E.coli were 86% and 60% while in CAI it was 14% and 40% correspondingly.Thus concluding that carbapenem resistance was more of focus in nosocomial infections because of repeated administration of antibiotics with prolonged stay makes bacteria resistant but contrary to this fact; above study results have indicated the presence of carbapenem resistance in the community as well due to the readily availability of antibiotics without prescription leading to their misuse. Henceforth serious measures should be brought up in the community for the awareness about multidrug resistance and antibiotic abuse.