Protective and Curative Effects of Afzelia africana Based diet on Alloxan induced Diabetic Rats

Abstract

The present study examines the Protective and Curative effects of Afzelia africana based diet on alloxan induced diabetic rats. Thirty two  male albino rats(Rattus novergicus) were divided into   two experimental groups (A, B). GroupA  were fed with standard formulated diet, GroupB were fed Afzelia africana based diet for four weeks, after which the two groups were sub-divided into subgroups A₁, A₂, and B₁, B₂.  Subgroups A₂, B₂ were induced with 150mg/kg body weight of alloxan by a single intraperitonial injection. Subgroups A₁, B₁ and B₂ were maintained on the samediet. Subgroup A₂ was fed Afzelia africana based diet while the experimental period lasted for two weeks.  Blood was collected from the rats through tail puncture for Glucose concentration determination. Blood sample was collected via cardiac puncture to assay  for Urea, Creatinine, Sodium ion(Na⁺), Potassium ion(K⁺) concentrations.  Significant decrease (P ≤ 0.05) were observed in blood glucose level in GroupsB compared with A at week4 before induction of diabetes, Creatinine level in GroupsA₂ compared with A₁ andGroupsB₂ compared with B_1. In conclusion, Afzelia africana based diet in addition to possessing anti-diabetic potential could be used to ameliorate kidney disorders.