Coordination chemistry of pyrazole derivatives

Abstract

Azole is the suffix used for five-membered ring containing two or more hetero-atoms, at least one of which is nitrogen for example pyrazoles and pyrazole derivatives such as 5-pyrazalones which were formed by reaction between hydrazines and β–Ketonic esters, e.g 3-methyl-1-phenylpyrazolone from phenylhydrazine and ethyleaceto acetate. This, on methylation gives antipyrine (phenazone, 2,3-dimethyl-1-phenylpyrazol-5-one), which is used in medicine as a febrifuge ^[1,2].