Formulation and Evaluation of Gastro Retentive Floating Tablets of Nimodipine
Abstract
Nimodipine is a dihydropyridine calcium channel blocker developed for the treatment of high blood pressure. Nimodipine has a half-life of 8-9 h, the bioavailability of 13% and it has narrow absorption window in upper part of the gastrointestinal tract (GIT), hence floating drug delivery system (FDDS) is preferred. During the study, nimodipine encapsulated floating tablets were formulated and characterized for enhancing residence time of drug in GIT.
Thus it is decided to prolong the gastric residence time in terms of making floating gastro retentive drug delivery system to increase drug absorption and hence bioavailability. Totally 12 formulations were formulated by using the above drugs by using two different techniques like Effervescent floating technique and Non Effervescent floating technique.Full Text:
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