Synthesis And Drug Release Study Of Voltaren Ophthalmic Solution By Using Natural Polymers

Abstract

A major problem being faced in ocular therapeutic is the attainment of an optimal concentration
at the site of action. The bioavailability of diclofenac sodium in the form of eye drop is very low
and when the drug is administered in the form of ophthalmic suspension it lead to irritation due
to particle size. So in the present study diclofenac sodium solution were developed with the aim
of promoting the prolong release of drug using natural polymer. Diclofenac sodium solution
were sterilised and assessed for various parameters like clearity, viscosity, pH, extrudability and
sterility. In Vitro drug release determined using dialysis membrane in phosphate buffer pH 7.4.
Ocular irritation studies were performed on albino rabbits.