Hantzsch synthesis of 5-Indolylpyrimidopyrido[2,3-d]pyrimidinones using PTSA under ultrasonic irradiation in aqueous medium

Abstract

Various derivatives of 5-Indolylpyrimidopyrido[2,3-d]pyrimidinone have been synthesized by multicomponent Hantzsch reaction of  one mole of 3-formylindole, two moles of barbituric/thiobarbituric acid and one mole of ammonium acetate using p-toluene sulfonic acid in aqueous medium under ultrasonic irradiation. Compared with conventional procedure, reaction carried out under ultrasonic irradiation in lesser time providing higher yields. Structures of these compounds have been deduced upon the basis of elemental analysis and spectral data (IR, NMR, mass).